Construction of synthetic life forms with genetic materials comprising unnatural nucleic acids
نویسندگان
چکیده
منابع مشابه
Nucleic acids: new life, new materials.
This article is part of the Nucleic acids: new life, new materials web‐themed issue Guest edited by: Mike Gait Medical Research Council, Cambridge, UK Ned Seeman New York University, USA David Liu Harvard University, USA Oliver Seitz Humboldt‐ Universität zu Berlin, Germany Makoto Komiyama University of Tsukuba, Japan Jason Micklefield University of Manchester, UK All articles in this issu...
متن کاملBio-inspired materials: unnatural life.
A t the turn of the nineteenth century, Pieter Harting and George Rainey laid the foundations of a science called “synthetic morphology”1. The inspiration for the name probably came from Wöhler’s discovery of urea synthesis in 1828, a breakthrough commonly perceived to mark the beginning of synthetic organic chemistry. The primary goal of Harting and Rainey’s synthetic morphology was to explain...
متن کاملEnhanced anti-HIV-1 activity of G-quadruplexes comprising locked nucleic acids and intercalating nucleic acids
Two G-quadruplex forming sequences, 5'-TGGGAG and the 17-mer sequence T30177, which exhibit anti-HIV-1 activity on cell lines, were modified using either locked nucleic acids (LNA) or via insertions of (R)-1-O-(pyren-1-ylmethyl)glycerol (intercalating nucleic acid, INA) or (R)-1-O-[4-(1-pyrenylethynyl)phenylmethyl]glycerol (twisted intercalating nucleic acid, TINA). Incorporation of LNA or INA/...
متن کاملUnderstanding nucleic acids using synthetic chemistry.
This Account describes work done in these laboratories that has used synthetic, physical organic, and biological chemistry to understand the roles played by the nucleobases, sugars, and phosphates of DNA in the molecular recognition processes central to genetics. The number of nucleobases has been increased from 4 to 12, generating an artificially expanded genetic information system. This syste...
متن کاملNon-natural nucleic acids for synthetic biology.
Genetic manipulation is an important facet of synthetic biology but can be complicated by undesired nuclease degradation. Incorporating non-natural nucleic acids into a gene could convey resistance to nucleases and promote expression. The compatibility of non-natural nucleosides with polymerases is reviewed with a focus on results from the past two years. Details are provided about how the diff...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Chinese Science Bulletin
سال: 2020
ISSN: 0023-074X
DOI: 10.1360/tb-2020-0474